@prefix this: <http://purl.org/np/RAytl9AFqJs8aXvS34NgLmtChr5_wZX4Cg1uGI9ntzZ7M> .
@prefix sub: <http://purl.org/np/RAytl9AFqJs8aXvS34NgLmtChr5_wZX4Cg1uGI9ntzZ7M#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0005052> bl:category bl:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0005052>;
    rdf:predicate bl:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB00904>;
    a rdf:Statement;
    rdfs:label "Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder which represents a major cost to healthcare services. IBS-D patients represent about one-third of the IBS population and are currently treated with antispasmodics, loperamide, bile acid sequestrants and antidepressants. Alosetron and rifaximin are also available in USA, ramosetron in Japan, Korea and Thailand and ondansetron as an off-label treatment.";
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    bl:has_population_context sub:cohort;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/28276811/>;
    bl:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Adults";
    bl:category bl:Cohort .
  
  <https://go.drugbank.com/drugs/DB00904> bl:category bl:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "L7B3xksOrZtTwhr+neU351oQTkKxdQ8d6a7uB9vlY5FxCWACAqmvtx4gDCK8OTP1qgKrtMHNis/p13yNWgfZjSb2q7c9F/CjxDznQctKGkNa3ny8089AEfMTBl7XUhx/OwnzPrsPBm9ZVzyQZDuz8mJZ+eLSRgXl8+tIIr2JWRc=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-05-28T17:40:31.342+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}