@prefix this: <http://purl.org/np/RAyYJo38dTw6Ss_FhpVjz6oxfvGmQQfDWzzNidHBxaRTs> .
@prefix sub: <http://purl.org/np/RAyYJo38dTw6Ss_FhpVjz6oxfvGmQQfDWzzNidHBxaRTs#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix hp: <http://purl.obolibrary.org/obo/HP_> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  drugbank:DB01267 a biolink:Drug;
    rdfs:label "Paliperidone";
    biolink:category biolink:Drug .
  
  hp:0000737 a biolink:Disease;
    rdfs:label "Irritability";
    biolink:category biolink:Disease .
  
  sub:association rdf:object hp:0000737;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB01267;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdfs:label "Stigler et al. [10] evaluated the effectiveness and tolerability of paliperidone for irritability in ASD. In this 8-week, prospective, open-label study, 21 (84%) of 25 subjects with ASD (mean age, 15.3 years) were considered responders to paliperidone (mean dosage, 7.1 mg/day), based on Clinical Global Impression (CGI)- Improvement and Aberrant Behaviour Checklist-Irritability sub- scale.v";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:31096228;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "Children and adolescents (mean age 15.3 years)";
    biolink:category biolink:Cohort;
    biolink:has_phenotype mondo:0005258 .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "NeH/8kC8VK3DP1/tbL1yIoGGwguuxVycaDYHS/YKAT8vvDD8/+NQBUt+nn0gOEvKZAtEJWG7dx5qf3KUY7GecQ/CYzgiGblTO7a2NDJELGVcI0k13Yb9uAPFcDNvQNIev0YqKJm5J3bUepHbAsFE8iCwoJOwEjVWB9cbIH+gYpk=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:50:42.254483"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}