. . . . . . . "[Herpes simplex virus 1 (HSV-1) recombinant R316 was constructed so as to convert the thymidine kinase (TK), a beta gene, into an alpha-regulated gene by insertion of the BamHI N fragment in the proper transcriptional orientation into the BglII cleavage site of the TK gene (L. E. Post, S. Mackem, and B. Roizman, Cell 24, 555-565 (1981).) The BamHI N fragment contains the promoter and regulatory domains of the alpha 4 gene in addition to an origin of viral DNA synthesis and the complete domain of the alpha 22 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:17:34+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .