@prefix this: <http://purl.org/np/RAu9H56k9QjpLnl5LVawV8-Y0zpILe9e755eeTuFbmE7Y> .
@prefix sub: <http://purl.org/np/RAu9H56k9QjpLnl5LVawV8-Y0zpILe9e755eeTuFbmE7Y#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0100081> a biolink:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0100081>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/DRUGBANK:DB01142>;
    a rdf:Statement;
    rdfs:label "Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001).";
    biolink:has_population_context sub:context;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/31622593>;
    biolink:relation <https://w3id.org/um/neurodkg/OffLabelIndication> .
  
  sub:context a biolink:Cohort;
    rdfs:label "Adults" .
  
  <https://identifiers.org/DRUGBANK:DB01142> a biolink:Drug .
}

sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-16T20:58:19.629539"^^xsd:dateTime .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "dQLrGebw1x7RtUmh3dbS4NpT5gUdN48SmRVQNHc64d2GTsTILdtkPFOcjoEAk6hJjcVSxD5EJFhU8ob96i+QihxDyIezY0GfdjPwsCP3IJWClQ9pvIFVD80uI/lqc8HmbxfdL+SHph3VrxG8pkC+l1tPNux0iSKoqfUXYOg0hy4=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2021-08-16T20:58:19.629539"^^xsd:dateTime;
    prov:wasAttributedTo <https://orcid.org/0000-0002-7641-6446>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}