@prefix this: <http://purl.org/np/RAt6pfYmUIFnibMYctavg4ZIvyUHoQfJ1y2aV0FcS7jnk> .
@prefix sub: <http://purl.org/np/RAt6pfYmUIFnibMYctavg4ZIvyUHoQfJ1y2aV0FcS7jnk#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix pav: <http://purl.org/pav/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix umls: <http://identifiers.org/umls/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix mesh: <http://id.nlm.nih.gov/mesh/> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
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    rdfs:label "ACE inhibitors";
    biolink:category biolink:ChemicalEntity .
  
  <http://identifiers.org/pubchem.compound/2541> a biolink:ChemicalEntity;
    rdfs:label "Candesartan";
    biolink:category biolink:ChemicalEntity .
  
  umls:C0749225 a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "systolic dysfunction";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/HP_0001712> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "left ventricular hypertrophy";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/MONDO_0005009> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "congestive heart failure";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/MONDO_0005010> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "coronary artery disease";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/MONDO_0005016> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "diabetic nephropathy";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/MONDO_0005044> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "hypertension";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
  <http://purl.obolibrary.org/obo/MONDO_0005068> a biolink:DiseaseOrPhenotypicFeature;
    rdfs:label "myocardial infarction";
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  
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    rdf:predicate biolink:treats;
    rdf:subject <http://identifiers.org/pubchem.compound/2541>;
    a biolink:Association;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:Association;
    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5ce07b9-ad0d-4b72-9daf-8662775af093> .
  
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  sub:_4 rdf:object mesh:D065087;
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  sub:_5 rdf:object <http://purl.obolibrary.org/obo/MONDO_0005009>;
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}

sub:provenance {
  sub:assertion prov:generatedAtTime "2022-10-13T13:05:17.366019"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-3668-2627;
    prov:wasQuotedFrom " Candesartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors. May be used as first line agent to delay progression of diabetic nephropathy. May also be used to treat uncomplicated hypertension and left ventricular hypertrophy." .
  
  biolink: pav:version "2.3.0" .
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