. . . . . . . "[Furthermore, we found the mRNA level of hypoxia-inducible factors 1? (HIF-1?) (1.54 � 0.13 fold in PC-3, p = 0.002, 1.62 � 0.12 fold in LNCaP, p = 0.001) and HIF-1? (1.67 � 0.23 fold in PC-3, p = 0.007; 1.75 � 0.26 fold in LNCaP, p=0.008) were upregulated in prostate cancer bone metastasis PC-3 and LNCaP cell lines in response to hypoxia, and revealed that the regulation of VEGF by HIF-1? and HIF-1? was possibly mediated by the activation of phosphatidylinositol 3-kinase pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:44+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .