. . . . . . . . . "Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2 contains information on trazodone and mirtazapine). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001)." . . . . . . "Adults" . . "2021-08-16T20:58:21.683895"^^ . "RSA" . "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" . "QuD/6CVjfKGi5a6X661Abu1gVTwMQ0XkPK5Q6yEDBoPapb1EcKGnEaZT0ESI23TxyUt2i7O3cLR8JxyP0tZHytYhHG6T0neYZIkNi6E8mdUgmeGadsvEKPwxSc1ovY8rORS2PybzJ3JxpLZwcNOGJOi8wBqHlc6AboPIXy+Hd6Q=" . . "2021-08-16T20:58:21.683895"^^ . . .