@prefix this: <http://purl.org/np/RApvz0KTvpeUh13pW3AT7Cqur78zw1641QohhEOSFHkyE> .
@prefix sub: <http://purl.org/np/RApvz0KTvpeUh13pW3AT7Cqur78zw1641QohhEOSFHkyE#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:association rdf:object <http://www.ebi.ac.uk/efo/EFO_0009854> ;
    rdf:predicate biolink:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB01221> ;
    a rdf:Statement ;
    rdfs:label "Off-label ketamine treatment has shown acute antidepressant effects that offer hope for patients with therapy-resistant depression. However, its potential for integration into treatment algorithms is controversial, not least because the evidence base for maintenance treatment with repeated ketamine administration is currently weak. Ketamine is also a drug of misuse, which has raised concerns regarding the target population." ;
    biolink:has_population_context sub:context ;
    biolink:provided_by <https://w3id.org/um/NeuroDKG> ;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/30202601> ;
    biolink:relation <https://w3id.org/um/neurodkg/OffLabelIndication> .
  sub:context a biolink:Cohort ;
    rdfs:label "adults" .
  <http://www.ebi.ac.uk/efo/EFO_0009854> a biolink:Disease .
  <https://identifiers.org/DRUGBANK:DB01221> a biolink:Drug .
}
sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-25T12:27:36.572421"^^xsd:dateTime .
}
sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "JYAxjIqL7BG7M5lHqJBgOtGUQCkALX8RKI5cah0jh8nFeY8dlRQrcxOUL7NJls2wIxqhihqFHo/RKAYJAj40/eI6z80wiwvs7jWjk8TFyEvtshmiifbYXEv8Vz0Dl1mM+ZTMxpVK8EoJxOQVRDPr4To6lNQ40SzcyHM3TWn+Hs8=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-25T12:27:36.572421"^^xsd:dateTime ;
    prov:wasAttributedTo <https://orcid.org/0000-0002-7641-6446> ;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}