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[Culture of osteocytic cells on these defective OA ECM resulted in a decrease of integrin?1 expression and the de-activation of FAK cell signaling pathway, which subsequently affected the initial osteocytic cell's attachment and functions including morphological abnormalities of cytoskeletal structures, focal adhesions, increased apoptosis, altered osteocyte specific gene expression and increased Matrix metalloproteinases (MMP-2) and -9 expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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