sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0013600> a biolink:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0013600> ;
    rdf:predicate biolink:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00656> ;
    a rdf:Statement ;
    rdfs:label "Trazodone, the most sedating atypical antidepressant, is widely used as an off-label hypnotic especially in the elderly. Although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. Two previous cases of trazodone-induced parkinsonism have been described after its prolonged use as an antidepressant; however, there is no published case of secondary parkinsonism caused by trazodone in a nondepressed person after its use as a hypnotic. Here, we present a case of rapid development of bradykinetic-rigid parkinsonism temporally linked to the use of trazodone as a hypnotic in a nondepressed elderly man" ;
    biolink:has_population_context sub:context ;
    biolink:provided_by <https://w3id.org/um/NeuroDKG> ;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/29634584> ;
    biolink:relation <https://w3id.org/um/neurodkg/OffLabelIndication> .
  sub:context a biolink:Cohort ;
    rdfs:label "elderly" .
  <https://identifiers.org/DRUGBANK:DB00656> a biolink:Drug .
}