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[Mechanistically, nutritional deficiencies could reduce hypoxia-inducible factor ? (HIF-1?) protein expression to increase C-MYC protein level, which in turn increased nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM) transcription to enhance the activity of OXPHOS, suggesting that metabolic reprogramming by the changes of microenvironment during the carcinogenesis can provide some novel therapeutic clues to traditional cancer treatments.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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