. . . . . . . "[Our results indicate that (1) single siRNAs complementary to ENaC subunits are sufficient to reduce ENaC transcripts, Na(+) channel activity, and fluid transport, but only silencing both the ? and ? ENaC subunits at the same time leads to an increase of ASF (from nearly 7 �m to more than 9 �m); (2) the ASF thickness obtained in this way is about half that measured after maximal CFTR stimulation in non-CF epithelia (10-14 �m); and (3) the pharmacological rescue of mutant CFTR increases the ASF to the same extent as ENaC silencing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:11:32+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .