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[Antibody blocking of monocyte TLR4 inhibited surface expression, determined by flow cytometry, of the major histocompatibility complex class I, CCR7, CD80, CD83 and CD86 on TAPCells, reduced interleukin (IL)-6 and tumor necrosis factor -? gene expression evaluated by qRT-PCR, and also inhibited the TAPCells-mediated interferon-? (IFN-?) secretion of melanoma-specific CD8(+) T cells determined by ELISpot (p < 0.01).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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