@prefix this: <
http://purl.org/np/RAZRqDsdRCWHa35VzOwFxRPb2e6pk_OTbJKSdw5Pnwa8M
> .
@prefix sub: <
http://purl.org/np/RAZRqDsdRCWHa35VzOwFxRPb2e6pk_OTbJKSdw5Pnwa8M#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix dct: <
http://purl.org/dc/terms/
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix bl: <
https://w3id.org/biolink/vocab/
> .
@prefix nkg: <
https://w3id.org/um/neurodkg/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/MONDO_0002046
>
bl:category
bl:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/MONDO_0002046
> ;
rdf:predicate
bl:treats
;
rdf:subject
<
https://go.drugbank.com/drugs/DB00181
> ;
a
rdf:Statement
;
rdfs:label
"Only a few medications are available for the treatment of alcohol use disorders (AUDs). Areas covered: This paper discusses approved AUD medications, including the opioid antagonists naltrexone and nalmefene (the latter is licensed for reduction of alcohol consumption only), the putative glutamate receptor antagonist acamprosate and the aldehyde dehydrogenase inhibitor disulfiram. It also covers off-label medications of interest, including topiramate, gabapentin, ondansetron, varenicline, baclofen, sodium oxybate and antidepressants." ;
bl:association_type
bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation
;
bl:has_population_context
sub:cohort
;
bl:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
bl:publications
<
https://pubmed.ncbi.nlm.nih.gov/28658981/
> ;
bl:relation
nkg:OffLabelIndication
.
sub:cohort
rdfs:label
"Adults" ;
bl:category
bl:Cohort
.
<
https://go.drugbank.com/drugs/DB00181
>
bl:category
bl:Drug
.
}
sub:provenance
{
sub:assertion
prov:wasAttributedTo
orcid:0000-0002-7641-6446
.
}
sub:pubinfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"N2XsExtuSmDqhsNyTCiQWOKqjpX7taazpFSQ99SWIAbaHj6jaicozOpU3De70jiapB2C44dxRltVljWre2CYuHWaTpJy4ddi2C3GPWJy8Dn4dVS+VwujvHRTEyfs1GiqCakDLzkAig6jOYw7NmIEeQTi6+2lX5kGTB7lWV/c4Bo=" ;
npx:hasSignatureTarget
this:
.
this:
dct:created
"2021-08-25T19:56:26.456+02:00"^^
xsd:dateTime
;
dct:creator
orcid:0000-0002-7641-6446
;
npx:supersedes
<
http://purl.org/np/RABKQoWBPe2xHiJO1OWK6-thNeldFTB3JfKDn0FT2dBSY
> ;
nt:wasCreatedFromProvenanceTemplate
<
http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM
> ;
nt:wasCreatedFromPubinfoTemplate
<
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
> , <
http://purl.org/np/RAjpBMlw3owYhJUBo3DtsuDlXsNAJ8cnGeWAutDVjuAuI
> ;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAZdZj78B6nKrP1Q00oFzsK07u7WdiY3sToz-H-H2nSgg
> .
}