. . . . . . . . . "Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" . . . . . "2021-08-24T15:53:47.29208" . "RSA" . "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" . "S36lxqMhE/il6hZ0x3opIf+BSGkgmrLS42CchAvMGjt03GhGQT20XdwHEBLps4EIevPEFYR3JCJttJowJ3HtWv4hSQ5sLxtGzcLW+7AD86Mrp/G3xGClqtMyQmf0MU7glLc83g8n8nenTaQOX37aaSuUPH+I3cZQJ1cSqTfX5ss=" . . "2021-09-13T13:11:54.555+02:00"^^ . . . "2021-08-24T15:53:47.29208" . . . . . . .