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[Knockout of c-Cbl decreases the T?RII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-? stimulation, while c-Cbl overexpression stabilizes T?RII and sensitizes leukemia cells to TGF-?. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to T?RII at Lys556 and Lys567.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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