. . . . . . . . . "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)." . . . . . . "Adults" . . "2021-08-16T20:58:13.507487"^^ . "RSA" . "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" . "jKLO3KFJt18DL3cYPb+vZaEjaIhModY//TQW+rSIG0zZoHcW4GZiWjt2Bmt7r78z09kHRMn1Wu8wc/vNX+e7ufwBCmSIsWD9HoG0HPdAKeoDJk3iip4bR1EkpLeNHOgBHXadwvfc0SmToPX4qzlOrEw4COr92C1sJw0q9W6G4Ow=" . . "2021-08-16T20:58:13.507487"^^ . . .