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Lycopene significantly increased the protein and mRNA expression of PPAR? and LXR? at 24 and 48 h, while the increased in the expression of ATP-binding cassette transporter 1 (ABCA1) was only evident 96 h. In addition, lycopene significantly decreased cellular total cholesterol levels and increased apoA1 protein expression at 96 h. Incubation of LNCaP cells with lycopene (10 ?M) in the presence (20 ?M) of a specific antagonist of PPAR? (GW9662) and LXR? (GGPP) restored the proliferation of LNCaP cells to the control levels and significantly suppressed protein expression of PPAR? and LXR? as well as increased cellular total cholesterol levels.]. 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