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http://example.org/nanopub-validator-example/RAPcU1hLZwbAvrdnvSEZeXrMJD61dDp-fCNAqpgTLeXZI
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http://example.org/MTBLS780
http://purl.org/dc/terms/description
The selection of bioengineering platform strains and engineering strategies to improve the stress resistance of Saccharomyces cerevisiae remains a pressing need in bio-based chemical production. Thus, a systematic effort to exploit the genotypic and phenotypic diversity to boost yeast’s industrial value is still urgently needed. Here, we analyzed 5400 growth curves obtained from 36 S. cerevisiae strains and comprehensively profiled their resistances against 13 industrially relevant stresses. We observed that bioethanol and brewing strains exhibit higher resistance against acidic conditions, however, plant isolates tend to have wider range of resistance, which may be associated with their metabolome and fluxome signatures in TCA cycle and fatty acid metabolism. By deep genomic sequencing we found that industrial strains have more genomic duplications especially affecting transcription factors, presenting disparate evolutionary paths in comparison to the environmental strains which have more InDels, gene deletions and strain-specific genes. Genome-wide association studies coupled with protein-protein interaction networks uncovered novel genetic determinants of stress resistances. These resistance-related engineering targets and strain rankings provide a valuable source for engineering significantly improved industrial platform strains.</br></br> This metabolomic study of 36 yeast strains measured intra- and extracellular metabolome under standard glucose medium, profiled by GS-MS. This is part of a multi-omic study on yeast strain collection.
http://example.org/MTBLS780
http://purl.org/dc/terms/identifier
MTBLS780
http://example.org/MTBLS780
http://purl.org/dc/terms/issued
2019-01-16^^xsd:date
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http://www.ebi.ac.uk/metabolights/MTBLS780
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http://purl.org/dc/terms/source
MetaboLights
http://example.org/MTBLS780
http://purl.org/dc/terms/title
Linking genetic, metabolic and phenotypic diversity 1 among S. cerevisiae strains using multi-omics associations
http://example.org/MTBLS780
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http://example.org/nanopub-validator-example/RAPcU1hLZwbAvrdnvSEZeXrMJD61dDp-fCNAqpgTLeXZI#provenance
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http://www.w3.org/ns/prov#hadPrimarySource
http://www.metabolomexchange.org
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http://example.org/nanopub-validator-example/RAPcU1hLZwbAvrdnvSEZeXrMJD61dDp-fCNAqpgTLeXZI
http://purl.org/dc/terms/created
2019-01-17T10:12:11+01:00
http://example.org/nanopub-validator-example/RAPcU1hLZwbAvrdnvSEZeXrMJD61dDp-fCNAqpgTLeXZI
http://purl.org/pav/createdBy
http://orcid.org/0000-0002-1267-0234
http://example.org/nanopub-validator-example/RAPcU1hLZwbAvrdnvSEZeXrMJD61dDp-fCNAqpgTLeXZI
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://purl.org/nanopub/x/ExampleNanopub