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diagnosed by bone mineral density bmd or prevalent vertebral fracture zoledronic acid injection reduces the incidence of fractures hip vertebral and non vertebral osteoporosis related fractures in patients at high risk of fracture defined as a recent low trauma hip fracture zoledronic acid injection reduces the incidence of new clinical fractures see clinical studies 14 1 zoledronic acid injection is indicated for prevention of osteoporosis in postmenopausal women see clinical studies 14 2 zoledronic acid injection is indicated for treatment to increase bone mass in men with osteoporosis see clinical studies 14 3 zoledronic acid injection is indicated for the treatment and prevention of glucocorticoid induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7 5 mg or greater of prednisone and who are expected to remain on glucocorticoids for at least 12 months see clinical studies 14 4 zoledronic acid 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