http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#Head http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://www.nanopub.org/nschema#hasAssertion http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#assertion http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://www.nanopub.org/nschema#hasProvenance http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#provenance http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://www.nanopub.org/nschema#hasPublicationInfo http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#pubinfo http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#assertion http://purl.obolibrary.org/obo/DOID_13268 https://w3id.org/biolink/vocab/category https://w3id.org/biolink/vocab/Disease http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.obolibrary.org/obo/DOID_13268 http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate https://w3id.org/biolink/vocab/treats http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association http://www.w3.org/1999/02/22-rdf-syntax-ns#subject https://identifiers.org/drugbank:DB00400 http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association http://www.w3.org/2000/01/rdf-schema#label "Griseofulvin is contraindicated in patients with porphyria or hepatocellular failure, and in individuals with a history of hypersensitivity to griseofulvin. Griseofulvin may cause fetal harm when administered to a pregnant woman. Two published cases of conjoined twins have been reported in patients taking griseofulvin during the first trimester of pregnancy, therefore, griseofulvin is contraindicated in women who are or may become pregnant during treatment. Women taking estrogen-containing oral contraceptives may be at increased risk of becoming pregnant while on griseofulvin (see also PRECAUTIONS, Drug Interactions Note: The Maximum Recommend Human Dose (MRHD) was set at 500 mg/day for the multiple of human exposure calculations performed in this label. If higher doses than 500 mg/day were used clinically, then the multiple of human exposure would be correspondingly reduced for that dose. For example, if a 1000 mg/day dose was administered to an individual, then the multiple of human exposure would be reduced by a factor of 2. 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Teratogenicity was also seen in mice when griseofulvin was administered in doses equivalent to 5g/kg/day [40X the MRHD based on BSA] for 2 consecutive days at various stages of the pregnancy." http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association https://w3id.org/biolink/vocab/provided_by https://w3id.org/um/NeuroDKG http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#association https://w3id.org/biolink/vocab/relation https://schema.org/MedicalContraindication https://identifiers.org/drugbank:DB00400 https://w3id.org/biolink/vocab/category https://w3id.org/biolink/vocab/Drug http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#provenance http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#assertion http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0000-0002-1468-3557 http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#pubinfo http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#sig http://purl.org/nanopub/x/hasAlgorithm RSA http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#sig http://purl.org/nanopub/x/hasSignature gqfLtZQfMHf3U6jy5Y0ALFddLljrsxmWmLFY9Sls00AOVp9IWiCs07lwOxeaqGdRbHnlC60gp+u34abc7hBm/eGzcsO0Yt273/ymqF6I670YVP1hOyjnfNB4Xq4g4W8gQ5AXtwtlDQmJeVtGPpG83wBNkcEfSrQkNAwBcmpqjRc= http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M#sig http://purl.org/nanopub/x/hasSignatureTarget http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://purl.org/dc/terms/created 2021-08-23T13:08:12.480+02:00 http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M http://purl.org/dc/terms/creator https://orcid.org/0000-0002-1468-3557 http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM http://purl.org/np/RANufIx5mGkeFv5uG3l2QbBSFSKHzC5oAa_EoP_ZL7d-M https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY