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[For testing the antitumor activity in syngeneic mouse xenograft models, we developed 'dual cytokine heterominibodies' with murine cytokines (mDCH). mDCH fusion proteins and, as controls, 'single cytokine heterominibodies' (SCH) carrying either murine GM-CSF (mGM-CSF) or murine IL-2 (mIL-2) were constructed, of which all retained the specific activities of cytokines and binding to the Ep-CAM antigen on human Ep-CAM transfected mouse colon carcinoma CT26-KSA cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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