sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_9408> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_9408> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB00009> ;
    a rdf:Statement ;
    rdfs:label "activase is a tissue plasminogen activator tpa indicated for the treatment of acute ischemic stroke ais 1 1 acute myocardial infarction ami to reduce mortality and incidence of heart failure 1 2 limitation of use in ami 1 2 acute massive pulmonary embolism pe for lysis 1 3 activase is indicated for the treatment of acute ischemic stroke exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment see contraindications 4 1 activase is indicated for use in acute myocardial infarction ami for the reduction of mortality and reduction of the incidence of heart failure limitation of use activase is indicated for the lysis of acute massive pulmonary embolism defined as acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments acute pulmonary emboli accompanied by unstable hemodynamics e g failure to maintain blood pressure without supportive measures" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB00009> bl:category bl:Drug .
}