[ { "@graph" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#pubInfo" } ] } ], "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#Head" }, { "@graph" : [ { "@id" : "http://purl.obolibrary.org/obo/MONDO_0005277", "@type" : [ "https://w3id.org/biolink/vocab/Disease" ] }, { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#association", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://purl.obolibrary.org/obo/MONDO_0005277" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "https://identifiers.org/DRUGBANK:DB00321" } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)." } ], "https://w3id.org/biolink/vocab/has_population_context" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#context" } ], "https://w3id.org/biolink/vocab/provided_by" : [ { "@id" : "https://w3id.org/um/NeuroDKG" } ], "https://w3id.org/biolink/vocab/publications" : [ { "@id" : "https://pubmed.ncbi.nlm.nih.gov/31622593" } ], "https://w3id.org/biolink/vocab/relation" : [ { "@id" : "https://w3id.org/um/neurodkg/OffLabelIndication" } ] }, { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#context", "@type" : [ "https://w3id.org/biolink/vocab/Cohort" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Adults" } ] }, { "@id" : "https://identifiers.org/DRUGBANK:DB00321", "@type" : [ "https://w3id.org/biolink/vocab/Drug" ] } ], "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion" }, { "@graph" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#assertion", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-08-16T20:58:07.416019" } ] } ], "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#provenance" }, { "@graph" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-08-16T20:58:07.416019" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "https://orcid.org/0000-0002-7641-6446" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate" : [ { "@id" : "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] }, { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#sig", "http://purl.org/nanopub/x/hasAlgorithm" : [ { "@value" : "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey" : [ { "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature" : [ { "@value" : "B7/KcuKQi6BEqCraWTskyVjmw0gI0NtvNM2px5+bjTLJMo/yPfB9MqN0kB4zsDflH+qsOZ2O5gID7R0//A4PjIuXVxWZt0wNAts1c9DhpuNzp92GJX6kJuCg0+3a4rjQhUUeYcaf9MQegnE7M1u5YuC/dZDPYgiymKf4ryDPYjw=" } ], "http://purl.org/nanopub/x/hasSignatureTarget" : [ { "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8" } ] } ], "@id" : "http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#pubInfo" } ]