@prefix this: <http://purl.org/np/RAMPlFJkJ_Ay0ovNx0rrJCbZod3DodODOmARn6_6iZ6OU> .
@prefix sub: <http://purl.org/np/RAMPlFJkJ_Ay0ovNx0rrJCbZod3DodODOmARn6_6iZ6OU#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  drugbank:DB01224 a biolink:Drug;
    rdfs:label "Quetiapine";
    biolink:category biolink:Drug .
  
  mondo:0005379 a biolink:Disease;
    rdfs:label "Neurotic disorder";
    biolink:category biolink:Disease .
  
  sub:association rdf:object mondo:0005379;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB01224;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdfs:label "The majority of antipsychotic use in children in Alberta is off-label and associated with disruptive behavior disorders, depression, and anxiety disorders. Quetiapine was mainly prescribed for neurotic disorder or depression, while aripiprazole was prescribed most frequently for conduct disorder or neurotic disorders.  (...) Information available in Table 1.";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:29453686;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "children and adolescents";
    biolink:category biolink:Cohort .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "DiIpUphkHKZLTJFQ8vMOPtYmmZ+LIHZohlSyjbN4Sdnf7Bp8ow8UVeudM8QC8JkYlmQSPGQnErVBkgyRpjk/obq7PtXN8PCcpmVrPswZvoxI9lFAonwgN9jNtn1AJrfHm+PmQvi2gNa4kAdl26n3LITMv3hp6KYmtyLCVqr/UqQ=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:55:09.892763"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}