@prefix this: <
http://purl.org/np/RAHTMDPT6XyaNv0R67W6y6nJwpAEHJF9fWpEuYXfoUtgo
> .
@prefix sub: <
http://purl.org/np/RAHTMDPT6XyaNv0R67W6y6nJwpAEHJF9fWpEuYXfoUtgo#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix biolink: <
https://w3id.org/biolink/vocab/
> .
@prefix ns1: <
https://w3id.org/np/o/ntemplate/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubInfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/MONDO_0007079
>
a
biolink:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/MONDO_0007079
> ;
rdf:predicate
biolink:treats
;
rdf:subject
<
https://identifiers.org/DRUGBANK:DB00657
> ;
a
rdf:Statement
;
rdfs:label
"The nicotinic-acetylcholine receptor (nAchR)- antagonist mecamylanine has been found to reduce the stimulus produced by ethanol in human lab studies. The nAchR-antagonist varenicline has also displayed positive effect in reducing alcohol consumption in multiple clinical trials. In this 12- week double-blind trial, participants (n 1⁄4 126) were randomized to either mecamylamine (10 mg daily) or placebo. No medication effect was found for reducing heavy drinking days (HDD) or alcohol craving. Smoking status had no effect on the results. The authors suggest that broad-spectrum nAchR-antagonists may not be beneficial in treat- ing AUD" ;
biolink:has_population_context
sub:context
;
biolink:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
biolink:publications
<
https://pubmed.ncbi.nlm.nih.gov/30973369
> ;
biolink:relation
<
https://w3id.org/um/neurodkg/OffLabelIndication
> .
sub:context
a
biolink:Cohort
;
rdfs:label
"Adults" .
<
https://identifiers.org/DRUGBANK:DB00657
>
a
biolink:Drug
.
}
sub:provenance
{
sub:assertion
prov:generatedAtTime
"2021-08-24T17:09:05.806678"^^
xsd:dateTime
.
}
sub:pubInfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"PO5HBEoj7x+D/G0vO4/1JUbwcMW/hSz7lCyAXQkkDcaLd5K6ImX6hTC66Nhskuqc7JCniz4Vex+YM7aXXKJYA4w5A2JNUD/4dDc2g2CUul0MoKDDP3CYWcecfVke3BlK1FZa0uCHFnjIEmgo3wy5gdOjGpn7UgOzXzCm/vVJaqo=" ;
npx:hasSignatureTarget
this:
.
this:
prov:generatedAtTime
"2021-08-24T17:09:05.806678"^^
xsd:dateTime
;
prov:wasAttributedTo
<
https://orcid.org/0000-0002-7641-6446
> ;
ns1:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}