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[Alterations of the p16(INK4a) gene were found in four of nine of the plaque lesions (hypermethylation in three samples and allelic loss in one sample) and seven of nine in the tumor lesions (hypermethylation in five samples and allelic loss in three samples).No case presented point mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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