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Drugs from all five classes of antidepressants have been investigated for use as smoking cessation aids (Shoaib and Buhidma, 2018). The second generation TCA nortriptyline is regarded as the most promising alternative to bupropion. This antidepressant mainly inhibits noradrenaline and serotonin transporters (Kripke, 2005). Antidepressants of the SSRI category are not effective, however, suggesting that serotonin does not play the main role in smoking addiction (Hughes et al., 2014).
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