@prefix this: <http://purl.org/np/RA9jovKmm4k8-GDJ1A8b5AoeLiXqMErrJEDAzxtdj7_Kc> .
@prefix sub: <http://purl.org/np/RA9jovKmm4k8-GDJ1A8b5AoeLiXqMErrJEDAzxtdj7_Kc#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  drugbank:DB00915 a biolink:Drug;
    rdfs:label "Amantadine";
    biolink:category biolink:Drug .
  
  mondo:0024613 a biolink:Disease;
    rdfs:label "bipolar depression";
    biolink:category biolink:Disease .
  
  sub:association rdf:object mondo:0024613;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB00915;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdfs:label """One of the off-label drugs that have an antidepressant effect is amantadine. The molecular mechanism of amantadine’s antidepressant action is not yet fully understood as the drug exerts its pharmacological effects through diverse brain signaling systems such as dopaminergic, noradrenergic, glutamatergic, and opioid systems. 
All patients treated with amantadine improved their depressive symptoms after 1 week of treatment.""";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:33096753;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "adults";
    biolink:category biolink:Cohort .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "gPfvN4Vo/hHAdi6iWdKURUykZyVHUwA5YeAE2f7bWWREyh2g6cqApDyeD55SpC4S1sKj3+Lj2If849dG/vprJoaz/b1Nwttjzmgu4FyAj6FpCQ/DL3/IVH/unLHSrun3TFvDQHzSP92p5SSU4UiNUhUdnZCpa+ft6GX6tCsnBgg=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:45:23.013619"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}