@prefix this: <http://purl.org/np/RA9aUJVFqVcV4C98yi3JsNAq2-n9vrBWb7_1JEcv1xHBc> .
@prefix sub: <http://purl.org/np/RA9aUJVFqVcV4C98yi3JsNAq2-n9vrBWb7_1JEcv1xHBc#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   drugbank:DB00363 a biolink:Drug ;
    rdfs:label "Clozapine" ;
    biolink:category biolink:Drug .
  mondo:0004985 a biolink:Disease ;
    rdfs:label "Bipolar disorder" ;
    biolink:category biolink:Disease .
  sub:association rdf:object mondo:0004985 ;
    rdf:predicate biolink:treats ;
    rdf:subject drugbank:DB00363 ;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    rdfs:label "Moreover, although the studies were uncontrolled, a significant body of literature has highlighted the potential benefit of clozapine in the treatment of acute mania, the depressive phase of BD, and in overall mood stabilization, with some evidence suggesting its use not only in treatment-resistant schizophrenia but also in treatment-refractory BD." ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    biolink:has_population_context sub:context ;
    biolink:publications pmid:31291215 ;
    biolink:relation ncit:C94303 .
  sub:context a biolink:Cohort ;
    rdfs:label "Adults" ;
    biolink:category biolink:Cohort .
}
sub:provenance {
   sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" ;
    npx:hasSignature "IjQwuQBlLORsKyy0lG3omdFV/MZJxiaLsiku++Ka2QK64W6KO+ULmEuRar4FZ1y/gJZV5qjI4bncezTzkhunPNurYf0LsVYFzhvdI3km2GtV6MEOqslV2yo1hPSw1sB27Wm+y4VWAhxT0EHt2G881wSPRUmDMK3m70FKYjahFwg=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2022-09-16T11:50:04.966887"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-1501-1082 ;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  biolink: pav:version "2.3.0" .
}