. . . . . . . . . "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)." . . . . . . "Adults" . . "2021-08-16T20:58:11.466301"^^ . "RSA" . "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" . "R1M3J03zEdQjvTbUcQuvDkvxfmBjOEr1x3V2a8FWPcs4QYd01c/TLJYr0QK7qJuXQ04u6bL7BfHM+WEpLDhKorulCgZjyHAG0h33aJc/nrlJolUEzBpxCoOcAx3KRVjW0Yzofnaz1mpC3PTKT5LLq+CfkOP2jINo2ckKVhls+FE=" . . "2021-08-16T20:58:11.466301"^^ . . .