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schizophrenia as well as in three 6 week trials with seroquel in patients with schizophrenia 14 1 acute treatment of manic or mixed episodes associated with bipolar i disorder both as monotherapy and as an adjunct to lithium or divalproex 1 2 adults efficacy was established with seroquel xr in one 3 week trial in patients with manic or mixed episodes associated with bipolar i disorder as well as two 12 week monotherapy trials and one 3 week adjunctive trial with seroquel in patients with manic episodes associated with bipolar i disorder 14 2 acute treatment of depressive episodes associated with bipolar disorder 1 2 adults efficacy was established with seroquel xr in one 8 week trial in patients with bipolar i or ii disorder as well as two 8 week trials with seroquel in patients with bipolar i or ii disorder 14 2 maintenance treatment of bipolar i disorder as an adjunct to lithium or divalproex 1 2 adults efficacy was established with seroquel in two maintenance trials in patients with bipolar i disorder 14 2 adjunctive treatment of major depressive disorder mdd 1 3 adults efficacy as an adjunct to antidepressants was established in two 6 week trials in patients with mdd who had an inadequate response to an antidepressant alone 14 3 seroquel xr is indicated for the treatment of schizophrenia the efficacy of seroquel xr in schizophrenia was established in one 6 week and one maintenance trial in adults with schizophrenia as well by extrapolation from three 6 week trials in adults with schizophrenia treated with seroquel see clinical studies seroquel xr is indicated for the acute treatment of manic or mixed episodes associated with bipolar i disorder both as monotherapy and as an adjunct to lithium or divalproex the efficacy of seroquel xr in manic or mixed episodes of bipolar i disorder was established in one 3 week trial in adults with manic or mixed episodes associated with bipolar i disorder as well by extrapolation from two 12 week monotherapy and one 3 week 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