@prefix this: <
http://purl.org/np/RA5i91jVBRKHpwDOPIiWGzt3c3Rs8wAqKRXxOYhegMxOI
> .
@prefix sub: <
http://purl.org/np/RA5i91jVBRKHpwDOPIiWGzt3c3Rs8wAqKRXxOYhegMxOI#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix biolink: <
https://w3id.org/biolink/vocab/
> .
@prefix ns1: <
https://w3id.org/np/o/ntemplate/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubInfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/MONDO_0005090
>
a
biolink:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/MONDO_0005090
> ;
rdf:predicate
biolink:treats
;
rdf:subject
<
https://identifiers.org/DRUGBANK:DB01267
> ;
a
rdf:Statement
;
rdfs:label
"Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" ;
biolink:has_population_context
sub:context
;
biolink:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
biolink:publications
<
https://pubmed.ncbi.nlm.nih.gov/31096228
> ;
biolink:relation
<
https://w3id.org/um/neurodkg/OffLabelIndication
> .
sub:context
a
biolink:Cohort
;
rdfs:label
"Children and adolescents (6-17 years)" .
<
https://identifiers.org/DRUGBANK:DB01267
>
a
biolink:Drug
.
}
sub:provenance
{
sub:assertion
prov:generatedAtTime
"2021-08-24T15:53:47.292085"^^
xsd:dateTime
.
}
sub:pubInfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"XmteTvqh/A6/5fPgkPFmun2ken/y/D/zOscm7VwpHX40Y9+7pr+5xVXnz4YbfnRr0ubmHYsV9E9zqlB6mikt2QmIW/PGuOkJUkBeTHBIgaTVSIFUO3qINduluDCuGtgL+7rbKXIhrn3acdOVb05kYpe51ENife4u16caBCqtdxE=" ;
npx:hasSignatureTarget
this:
.
this:
prov:generatedAtTime
"2021-08-24T15:53:47.292085"^^
xsd:dateTime
;
prov:wasAttributedTo
<
https://orcid.org/0000-0002-7641-6446
> ;
ns1:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}