@prefix this: <http://purl.org/np/RA5i91jVBRKHpwDOPIiWGzt3c3Rs8wAqKRXxOYhegMxOI> .
@prefix sub: <http://purl.org/np/RA5i91jVBRKHpwDOPIiWGzt3c3Rs8wAqKRXxOYhegMxOI#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0005090> a biolink:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0005090> ;
    rdf:predicate biolink:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB01267> ;
    a rdf:Statement ;
    rdfs:label "Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" ;
    biolink:has_population_context sub:context ;
    biolink:provided_by <https://w3id.org/um/NeuroDKG> ;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/31096228> ;
    biolink:relation <https://w3id.org/um/neurodkg/OffLabelIndication> .
  sub:context a biolink:Cohort ;
    rdfs:label "Children and adolescents (6-17 years)" .
  <https://identifiers.org/DRUGBANK:DB01267> a biolink:Drug .
}
sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-24T15:53:47.292085"^^xsd:dateTime .
}
sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "XmteTvqh/A6/5fPgkPFmun2ken/y/D/zOscm7VwpHX40Y9+7pr+5xVXnz4YbfnRr0ubmHYsV9E9zqlB6mikt2QmIW/PGuOkJUkBeTHBIgaTVSIFUO3qINduluDCuGtgL+7rbKXIhrn3acdOVb05kYpe51ENife4u16caBCqtdxE=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-24T15:53:47.292085"^^xsd:dateTime ;
    prov:wasAttributedTo <https://orcid.org/0000-0002-7641-6446> ;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}