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[Long-term use of valproic acid (VA), a well-tolerated anticonvulsant agent widely used for treating epilepsia, has been recently shown to inhibit histone deacetylases, which in turn are involved in the regulation of the expression of estrogen receptor alpha (ERalpha) by suppressing gene transcription.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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