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testicular failure due to cryptorchidism bilateral torsion orchitis vanishing testis syndrome orchiectomy klinefelter s syndrome chemotherapy or toxic damage from alcohol or heavy metals these men usually have low serum testosterone concentrations and gonadotropins follicle stimulating hormone fsh luteinizing hormone lh above the normal range hypogonadotropic hypogonadism congenital or acquired gonadotropin or luteinizing hormone releasing hormone lhrh deficiency or pituitary hypothalamic injury from tumors trauma or radiation these men have low testosterone serum concentrations but have gonadotropins in the normal or low range aveed should only be used in patients who require testosterone replacement therapy and in whom the benefits of the product outweigh the serious risks of pulmonary oil microembolism and anaphylaxis limitations of use safety and efficacy of aveed in men with age related hypogonadism also referred to as late onset hypogonadism have not been established safety and 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