@prefix this: <http://purl.org/np/RA446hNvw07wY-Ua_dtulJSrQD6kH7PZXaQb-b-Qw9YlI> .
@prefix sub: <http://purl.org/np/RA446hNvw07wY-Ua_dtulJSrQD6kH7PZXaQb-b-Qw9YlI#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0005452> bl:category bl:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0005452>;
    rdf:predicate bl:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB01255>;
    a rdf:Statement;
    rdfs:label "Of relevance, lisdexamfetamine dimesylate, a psy- chostimulant approved for the treatment of ADHD, has been recently assessed and approved for the treat- ment of moderate to severe binge eating disorder in adults.5,6 In a phase 2 efficacy and safety trial, pa- tients with binge eating disorder who were prescribed doses of 50 and 70 mg/day doses of lisdexamfetamine demonstrated reduced binge eating days per week, greater binge eating cessation rates, and greater rates of clinical global improvement at 11 weeks compared with the placebo control group";
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    bl:has_population_context sub:cohort;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/28125174/>;
    bl:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "Adults";
    bl:category bl:Cohort .
  
  <https://go.drugbank.com/drugs/DB01255> bl:category bl:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
    npx:hasSignature "PCDPwKiHmsH80UaIs0rt9FS3fcNixmWn4eRPirgozVk8qKEPH2rM6RjOErxw1MP+93czBmLUs92nPOhwPM428RQjRO+Z6b3qYvi7ZV+J2BWtXOcqT76T0GLpNWQDiM6iEfOHh4SUAkg8VqFCerh+2uiXK8xnHHS3JmY/JkjXzUQ=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-05-31T10:52:02.178+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}