@prefix this: <http://purl.org/np/RA3lYITjFDUH8IWDTi07Q7zQyprSf__pJ7VudwjMhRwoQ> .
@prefix sub: <http://purl.org/np/RA3lYITjFDUH8IWDTi07Q7zQyprSf__pJ7VudwjMhRwoQ#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:association rdf:object <https://identifiers.org/MONDO:0005090>;
    rdf:predicate bl:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB00107>;
    a rdf:Statement;
    rdfs:label "A retrospective chart review evaluated outcomes for 5 young adult inpatients with treatment-resistant schizophrenia who were prescribed off-label oxytocin (OT; 10 IU/sublingual, 1 time per day, to 20 IU/sublingual, 3 times per day) after their therapeutic response to clozapine plateaued (dose range: 200 to 600 mg). The augmented treatment was well tolerated and continued for at least 1 year after discharge from the hospital, with continued outpatient follow-up by the treating psychiatrist. Evaluation included the Positive and Negative Syndrome Scale and clinical review based on both self and parent/guardian reports.";
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/32343282>;
    bl:relation nkg:OffLabelIndication .
  
  <https://go.drugbank.com/drugs/DB00107> bl:category bl:Drug .
  
  <https://identifiers.org/MONDO:0005090> bl:category bl:Disease .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "Wa0ALDSr4UufGWCqblxQi+ZJp6NNebgVfS3tWOgc2U+3hbJ5Vt9MLY9sDnUzFi/iCKxKRZcFIgEsxbuSxwyeJJBbgM5l72seHUA8YWXb8Jt1PEeWbUf6sGfV44Rzl5lX5CTKY3jMsmbqYlqtvX3/Q+wXEwWcG72Sh1RJvCBZ3+0=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-05-24T17:43:15.737+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1468-3557;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAZdZj78B6nKrP1Q00oFzsK07u7WdiY3sToz-H-H2nSgg> .
}