@prefix this: <http://purl.org/np/RA2plesgmHbxVeX02hRRQwCqTxProxTT8hq58ZwtSfWok> .
@prefix sub: <http://purl.org/np/RA2plesgmHbxVeX02hRRQwCqTxProxTT8hq58ZwtSfWok#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/MONDO_0002046> bl:category bl:Disease .
  
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0002046>;
    rdf:predicate bl:treats;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00657>;
    a rdf:Statement;
    rdfs:label "The nicotinic-acetylcholine receptor (nAchR)- antagonist mecamylanine has been found to reduce the stimulus produced by ethanol in human lab studies. The nAchR-antagonist varenicline has also displayed positive effect in reducing alcohol consumption in multiple clinical trials. In this 12- week double-blind trial, participants (n 1⁄4 126) were randomized to either mecamylamine (10 mg daily) or placebo. No medication effect was found for reducing heavy drinking days (HDD) or alcohol craving. Smoking status had no effect on the results. The authors suggest that broad-spectrum nAchR-antagonists may not be beneficial in treat- ing AUD";
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/30973369>;
    bl:relation nkg:OffLabelIndication .
  
  <https://identifiers.org/DRUGBANK:DB00657> bl:category bl:Drug .
}

sub:provenance {
  sub:assertion prov:generatedAtTime "2021-08-24T17:09:05.80667" .
}

sub:pubinfo {
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    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-25T18:14:02.481+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-7641-6446;
    npx:supersedes <http://purl.org/np/RAHTMDPT6XyaNv0R67W6y6nJwpAEHJF9fWpEuYXfoUtgo>;
    prov:generatedAtTime "2021-08-24T17:09:05.80667";
    prov:wasAttributedTo orcid:0000-0002-7641-6446;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RAcm8OurwUk15WOgBM9wySo-T3a5h6as4K8YR5MBrrxUc>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RA2vCBXZf-icEcVRGhulJXugTGxpsV5yVr9yqCI1bQh4A>,
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    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}