[ { "@graph" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#pubInfo" } ] } ], "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#Head" }, { "@graph" : [ { "@id" : "http://purl.obolibrary.org/obo/MONDO_0008114", "@type" : [ "https://w3id.org/biolink/vocab/Disease" ] }, { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#association", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://purl.obolibrary.org/obo/MONDO_0008114" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "https://identifiers.org/DRUGBANK:DB00363" } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Clozapine is not recommended for OCD due to poor evidence of efficacy [170]. In addition, several case reports and clinical studies support the association of clozapine with worsening or onset of obsessive-compulsive symptoms in patients with a psychotic disorder [171-176]. At least 20% of individuals treated with clozapine (and other antiserotonergic antipsychotics) would experience worsening or emergence of obsessive-compulsive symptoms [177], which are dose-related [178] and generally reversible upon discontinuation of clozapine treatment and switch to a different antipsychotic [179]" } ], "https://w3id.org/biolink/vocab/has_population_context" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#context" } ], "https://w3id.org/biolink/vocab/provided_by" : [ { "@id" : "https://w3id.org/um/NeuroDKG" } ], "https://w3id.org/biolink/vocab/publications" : [ { "@id" : "https://pubmed.ncbi.nlm.nih.gov/30101713" } ], "https://w3id.org/biolink/vocab/relation" : [ { "@id" : "https://w3id.org/um/neurodkg/OffLabelIndication" } ] }, { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#context", "@type" : [ "https://w3id.org/biolink/vocab/Cohort" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "adults" } ] }, { "@id" : "https://identifiers.org/DRUGBANK:DB00363", "@type" : [ "https://w3id.org/biolink/vocab/Drug" ] } ], "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#assertion" }, { "@graph" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#assertion", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-08-25T14:52:29.045065" } ] } ], "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#provenance" }, { "@graph" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2021-08-25T14:52:29.045065" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "https://orcid.org/0000-0002-7641-6446" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate" : [ { "@id" : "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] }, { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#sig", "http://purl.org/nanopub/x/hasAlgorithm" : [ { "@value" : "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey" : [ { "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature" : [ { "@value" : "GsbY5Rbf6Gbvaiit2lQi84DcwIpIcxQg1AFco8HJT0BKmN2VqnPquPkYM9KgdePNBhe65iEH+k+zJjAeLnsqZdoNsCl55SrU56jJTiDFSld3kMbWYkyXoMrWYlLsyGSo8z9O9/MXAvNbpoRLYIsp+6P1gs2DqdM5mr/Q0Wf4ve8=" } ], "http://purl.org/nanopub/x/hasSignatureTarget" : [ { "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0" } ] } ], "@id" : "http://purl.org/np/RA2RqUnRCJvJU4BCc_aaDIS59BFJ2GM1MueMUZXBMvbG0#pubInfo" } ]