[ { "@graph" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#pubInfo" } ] } ], "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#Head" }, { "@graph" : [ { "@id" : "http://identifiers.org/drugbank/DB00273", "@type" : [ "https://w3id.org/biolink/vocab/Drug" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Topiramate" } ], "https://w3id.org/biolink/vocab/category" : [ { "@id" : "https://w3id.org/biolink/vocab/Drug" } ] }, { "@id" : "http://purl.obolibrary.org/obo/DOID_1574", "@type" : [ "https://w3id.org/biolink/vocab/Disease" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "alcohol use disorder" } ], "https://w3id.org/biolink/vocab/category" : [ { "@id" : "https://w3id.org/biolink/vocab/Disease" } ] }, { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#association", "@type" : [ "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://purl.obolibrary.org/obo/DOID_1574" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://identifiers.org/drugbank/DB00273" } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "It has been tested in multiple clinical trials since it could be promising in AUD treatment. Topiramate decreases reinforcing effects of alcohol and craving. A meta-analysis, based on data from seven random studies (2003-2014), suggested that topiramate might have beneficial effects in AUD treatment but because of its many side effects, the use is limited. The most common side effects are cognitive dysfunction, paresthesia, and taste abnormalities." } ], "https://w3id.org/biolink/vocab/aggregator_knowledge_source" : [ { "@id" : "https://w3id.org/biolink/infores/knowledge-collaboratory" } ], "https://w3id.org/biolink/vocab/category" : [ { "@id" : "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" } ], "https://w3id.org/biolink/vocab/has_population_context" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#context" } ], "https://w3id.org/biolink/vocab/publications" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/29912214" } ], "https://w3id.org/biolink/vocab/relation" : [ { "@id" : "http://purl.obolibrary.org/obo/NCIT_C94303" } ] }, { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#context", "@type" : [ "https://w3id.org/biolink/vocab/Cohort" ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "adults" } ], "https://w3id.org/biolink/vocab/category" : [ { "@id" : "https://w3id.org/biolink/vocab/Cohort" } ] } ], "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#assertion" }, { "@graph" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#assertion", "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "https://orcid.org/0000-0002-7641-6446" } ] } ], "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#provenance" }, { "@graph" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac", "http://www.w3.org/ns/prov#generatedAtTime" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2022-09-16T11:54:28.861339" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "https://orcid.org/0000-0002-1501-1082" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate" : [ { "@id" : "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] }, { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#sig", "http://purl.org/nanopub/x/hasAlgorithm" : [ { "@value" : "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey" : [ { "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature" : [ { "@value" : "UHV/mWJ/aaTQvaW8DtB2T7uqTzMs/A5eJFt0LFsdGsIukNb6MkCqfq4Fsg2Bc6aUViEeuFLminLuKe8fPkiKyBMh4BgBGkEaEm+J1+K6utMFazSitn3CyllCJpmGz3JHjdvx1Z3n7oAJiN9GE7uWdcQFlB9tfueqxWvWq6fGi0M=" } ], "http://purl.org/nanopub/x/hasSignatureTarget" : [ { "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac" } ] }, { "@id" : "https://w3id.org/biolink/vocab/", "http://purl.org/pav/version" : [ { "@value" : "2.3.0" } ] } ], "@id" : "http://purl.org/np/RA-Q8OR6_xjIlVC0A0Z8oz1L-rktMyTGunyUFlhPxj2ac#pubInfo" } ]