@prefix this: <
http://purl.org/np/RA-FUyznjPRCflHSPhB0Ex-nUNohkyd-piGntcZYVUmsc
> .
@prefix sub: <
http://purl.org/np/RA-FUyznjPRCflHSPhB0Ex-nUNohkyd-piGntcZYVUmsc#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix biolink: <
https://w3id.org/biolink/vocab/
> .
@prefix ns1: <
https://w3id.org/np/o/ntemplate/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubInfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/DOID_1574
>
a
biolink:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/DOID_1574
> ;
rdf:predicate
biolink:treats
;
rdf:subject
<
https://identifiers.org/DRUGBANK:DB00273
> ;
a
rdf:Statement
;
rdfs:label
"It has been tested in multiple clinical trials since it could be promising in AUD treatment. Topiramate decreases reinforcing effects of alcohol and craving. A meta-analysis, based on data from seven random studies (2003-2014), suggested that topiramate might have beneficial effects in AUD treatment but because of its many side effects, the use is limited. The most common side effects are cognitive dysfunction, paresthesia, and taste abnormalities. " ;
biolink:has_population_context
sub:context
;
biolink:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
biolink:publications
<
https://pubmed.ncbi.nlm.nih.gov/29912214
> ;
biolink:relation
<
https://w3id.org/um/neurodkg/OffLabelIndication
> .
sub:context
a
biolink:Cohort
;
rdfs:label
"adults" .
<
https://identifiers.org/DRUGBANK:DB00273
>
a
biolink:Drug
.
}
sub:provenance
{
sub:assertion
prov:generatedAtTime
"2021-08-26T09:18:22.500151"^^
xsd:dateTime
.
}
sub:pubInfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"SEjDg+HR+1PTkAxkVhfx6PCxXLSeJp7BroKlkBWpW7RIha//8LeMaOrYub5nRSacdfwdQWNymqFVSjsONNpUwvRQmNQg0LxgpwoZcQC7R7MFLhR4ArCIgqE0k81T1fCXagk45ajNyJDhrLXVzBxXJZQaIwENQspjRyxaVWAD9Hs=" ;
npx:hasSignatureTarget
this:
.
this:
prov:generatedAtTime
"2021-08-26T09:18:22.500151"^^
xsd:dateTime
;
prov:wasAttributedTo
<
https://orcid.org/0000-0002-7641-6446
> ;
ns1:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}